Development

Python backend development expertise for FastAPI, security patterns, database operations, Upstash integrations, and code quality. Use when: (1) Building REST APIs with FastAPI, (2) Implementing JWT/OAuth2 authentication, (3) Setting up SQLAlchemy/async databases, (4) Integrating Redis/Upstash caching, (5) Refactoring AI-generated Python code (deslopification), (6) Designing API patterns, or (7) Optimizing backend performance.

Official Google SEO guide covering search optimization, best practices, Search Console, crawling, indexing, and improving website search visibility based on official Google documentation

Build, test, and explain regular expressions against sample text or files using CLI tools (rg, python) and specific regex flavors. Use when asked to craft, debug, or validate regexes or search patterns.

Plan work before coding: do repo research, analyze options/risks, and ask clarifying questions before proposing an implementation plan. Use when the user asks for a plan, design/approach, scope breakdown, or implementation steps.

Create or update root and nested AGENTS.md files that document scoped conventions, monorepo module maps, cross-domain workflows, and (optionally) per-module feature maps (feature -> paths, entrypoints, tests, docs). Use when the user asks for AGENTS.md, nested agent instructions, or a module/feature map.

Automatically formats and validates code files using Prettier and other formatting tools. Use when users mention "format my code", "fix formatting", "apply code style", "check formatting", "make code consistent", or "clean up code formatting". Handles JavaScript, TypeScript, JSON, CSS, Markdown, and many other file types.

This skill provides comprehensive security assessment and vulnerability management tools through x-cmd CLI, including network reconnaissance with Shodan, vulnerability scanning with OSV, and known exploited vulnerability tracking with KEV. This skill should be used when users need to perform security assessments, vulnerability research, network reconnaissance, or security monitoring from command line interfaces.

This skill provides access to various knowledge search tools through x-cmd CLI, including Hacker News, Wikipedia, DuckDuckGo search, RFC documents, Project Gutenberg books, and Stack Exchange. This skill should be used when users need to search for technical information, browse online knowledge bases, or access documentation from command line interfaces.

This skill provides comprehensive Git and code hosting platform management tools through x-cmd CLI, including GitHub, GitLab, Codeberg, Forgejo integration, and Git hooks management. This skill should be used when users need to manage Git repositories, work with code hosting platforms, automate Git workflows, or configure Git hooks from command line interfaces.

Query STRING API for protein-protein interactions (59M proteins, 20B interactions). Network analysis, GO/KEGG enrichment, interaction discovery, 5000+ species, for systems biology.

Query Reactome REST API for pathway analysis, enrichment, gene-pathway mapping, disease pathways, molecular interactions, expression analysis, for systems biology studies.

Multi-objective optimization framework. NSGA-II, NSGA-III, MOEA/D, Pareto fronts, constraint handling, benchmarks (ZDT, DTLZ), for engineering design and optimization problems.

Laboratory automation toolkit for controlling liquid handlers, plate readers, pumps, heater shakers, incubators, centrifuges, and analytical equipment. Use this skill when automating laboratory workflows, programming liquid handling robots (Hamilton STAR, Opentrons OT-2, Tecan EVO), integrating lab equipment, managing deck layouts and resources (plates, tips, containers), reading plates, or creating reproducible laboratory protocols. Applicable for both simulated protocols and physical hardwa...

Integration with protocols.io API for managing scientific protocols. This skill should be used when working with protocols.io to search, create, update, or publish protocols; manage protocol steps and materials; handle discussions and comments; organize workspaces; upload and manage files; or integrate protocols.io functionality into workflows. Applicable for protocol discovery, collaborative protocol development, experiment tracking, lab protocol management, and scientific documentation.

Access RCSB PDB for 3D protein/nucleic acid structures. Search by text/sequence/structure, download coordinates (PDB/mmCIF), retrieve metadata, for structural biology and drug discovery.

Lab automation platform for Flex/OT-2 robots. Write Protocol API v2 protocols, liquid handling, hardware modules (heater-shaker, thermocycler), labware management, for automated pipetting workflows.

Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.

Microscopy data management platform. Access images via Python, retrieve datasets, analyze pixels, manage ROIs/annotations, batch processing, for high-content screening and microscopy workflows.

Comprehensive biosignal processing toolkit for analyzing physiological data including ECG, EEG, EDA, RSP, PPG, EMG, and EOG signals. Use this skill when processing cardiovascular signals, brain activity, electrodermal responses, respiratory patterns, muscle activity, or eye movements. Applicable for heart rate variability analysis, event-related potentials, complexity measures, autonomic nervous system assessment, psychophysiology research, and multi-modal physiological signal integration.

Latch platform for bioinformatics workflows. Build pipelines with Latch SDK, @workflow/@task decorators, deploy serverless workflows, LatchFile/LatchDir, Nextflow/Snakemake integration.

Direct REST API access to KEGG (academic use only). Pathway analysis, gene-pathway mapping, metabolic pathways, drug interactions, ID conversion. For Python workflows with multiple databases, prefer bioservices. Use this for direct HTTP/REST work or KEGG-specific control.

Access Human Metabolome Database (220K+ metabolites). Search by name/ID/structure, retrieve chemical properties, biomarker data, NMR/MS spectra, pathways, for metabolomics and identification.

Query openFDA API for drugs, devices, adverse events, recalls, regulatory submissions (510k, PMA), substance identification (UNII), for FDA regulatory data analysis and safety research.

DNAnexus cloud genomics platform. Build apps/applets, manage data (upload/download), dxpy Python SDK, run workflows, FASTQ/BAM/VCF, for genomics pipeline development and execution.

Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele functions, for precision medicine and genotype-guided dosing decisions.

Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research and patient matching.

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing prote...

Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.

Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for complex artifacts requiring state management, routing, or shadcn/ui components - not for simple single-file HTML/JSX artifacts.

Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with specialized knowledge, workflows, or tool integrations.

Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).

Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, or applications. Generates creative, polished code that avoids generic AI aesthetics.

Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel. Use it when brand colors or style guidelines, visual formatting, or company design standards apply.

Creating algorithmic art using p5.js with seeded randomness and interactive parameter exploration. Use this when users request creating art using code, generative art, algorithmic art, flow fields, or particle systems. Create original algorithmic art rather than copying existing artists' work to avoid copyright violations.

Git worktree management for parallel SPEC development with isolated workspaces, automatic registration, and seamless MoAI-ADK integration

Comprehensive development workflow specialist combining TDD, debugging, performance optimization, code review, and quality assurance into unified development workflows

Enterprise template management with code boilerplates, feedback templates, and project optimization workflows

SPEC workflow orchestration with EARS format, requirement clarification, and Plan-Run-Sync integration for MoAI-ADK development methodology

Integrated project management system with documentation, language initialization, and template optimization modules

Enhanced Just-In-Time document loading system that intelligently discovers, loads, and caches relevant documentation based on user intent and project context. Use when users need specific documentation, when working with new technologies, when answering domain-specific questions, or when context indicates documentation gaps.

Vercel edge deployment specialist covering Edge Functions, Next.js optimization, preview deployments, and ISR. Use when deploying Next.js or edge-first applications.

Railway container deployment specialist covering Docker, multi-service architectures, persistent volumes, and auto-scaling. Use when deploying containerized full-stack applications.

Firebase Firestore specialist covering NoSQL patterns, real-time sync, offline caching, and Security Rules. Use when building mobile-first apps with offline support, implementing real-time listeners, or configuring Firestore security.

Firebase Authentication specialist covering Google ecosystem, social auth, phone auth, and mobile-first patterns. Use when building Firebase-backed or Google ecosystem apps.

Clerk modern authentication specialist covering WebAuthn, passkeys, passwordless, and beautiful UI components. Use when implementing modern auth with great UX.

Figma MCP integration specialist for design system extraction, component generation, and design-to-code workflows. Use when integrating Figma designs into development.

Moai Lib Shadcn Ui - Professional implementation guide

Enterprise Nextra documentation framework with Next.js

TypeScript 5.9+ development specialist covering React 19, Next.js 16 App Router, type-safe APIs with tRPC, Zod validation, and modern TypeScript patterns. Use when developing TypeScript applications, React components, Next.js pages, or type-safe APIs.